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Abstract

SPATIAL AND WORKING MEMORY ENHANCING ACTIVITY OF PONGAMIA PINNATA LEAVES EXTRACTS IN RATS

S. K. Sarje*, Shagufta Farooqui, Muttewar Arti, Navghare Balaji and Shinde Dinesh

ABSTRACT

Memory is the ability of an individual to record sensory stimuli & retain them over short or long periods of time & recall the same at a later date when needed. Short and long term memory loss may result from deteriorating cerebral mechanisms due to different causes having impact on the quality of life. Memory enhancer can improve thinking, memory, and alertness in people with Alzheimer‟s disease that affect the mind. The Leaves of Pongamia pinnata pierre (Linn) belongs to the family Fabaceae is used as a digestive, laxative, anti-helmintic and are good for diarrhea, leprosy, dyspepsia and cough. Traditonally it is also used as Neuroprotective as it contains Chalcone derivatives. Memory refers to retaining and recalling information over a period of time, depending upon the nature of cognitive task you are required to perform. The present study designed to assess the memory enhancing potential of Pongamia pinnata leaves extracts in wistar albino rats. In this study the two models has been selected under which in radial arm maze model in rats is used to evaluate working and reference memory errors and the Morris water maze is used to evaluate the retrieval of memory. The extract was administered orally in two doses (100 and 200 mg/kg p.o) for a period of 8 days for radial arm and 11 days for water maze test. Piracetam, 200mg/kg i.p, was used as standard drug treatment. Radial arm maze (RAM) was used to evaluate number of correct entries and time spent in baited arms as well as the latency to find the food. In Morris water maze used to evaluate the escape latency and time spent in target quadrant. The both the extracts of Pongamia pinnata at conc.200mg/kg, o.p. showed significantly increase in number correct entries and time spent in baited arms as well as increase in latency to find food, besides this in Morris water maze both the extracts i.e PPEA- 200 and PPETH-200 mg/kg, o.p. showed significantly decreased in escape latency and increased in time spent in target quadrants as compared to standard (Pirecetam) and highly significant difference when compared to control. The present study revealed that the Pongamia pinnata leaves extracts has potential to enhance the Memory and this might be due to presence of flavones and chalcone deriavtives such as Pongone, galbone, Pongalabol etc.

Keywords: Pongamia pinnata leaves, Ethyl acetate and Ethanolic extract, Phytochemical screening, Memory enhancing activity.


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