Abstract

PHYTOCHEMICAL INVESTIGATION AND PHARMACOLOGICAL EVALUATION OF BOUGAINVILLEA SPECTABILIS FOR HEPATOPROTECTIVE ACTIVITY

S. K. Sarje*, Kadam V. M., Hede A. B., Ware S. V., Patil V. D. and Jadhav V. R.

ABSTRACT

The presence study aimed to evaluate the Hepatoprotective effect of Bougainvillea spectabilis stems extract against liver injury induced by carbon tetrachloride (CCl4). Both male and female wistar albino rats were used, rats were injected i.p. with CCl4 (1ml/kg) mixed in liquid paraffin in portion (1:1), three times in a seven days and treated orally with Bougainvillea spectabilis (100 mg/kg and 200 mg/kg) stems extract daily for seven days and compared with a group of rats injected i.p. with CCl4 (1ml/kg) mixed in liquid paraffin in portion (1:1), three times in a seven days. Bougainvillea spectabilis plant belonging to family Nyctaginaceae used in various diseases like Hepatitis.(Leaves), Diarrhea, Inflammation, Stomach acidity, Cough, sore throat and other respiratory diseases, Leucorrhea, Ulcer, Microbial infection, Diabeties, Hyperlipidemia, Cancer, It have antifertility property. Carbon tetrachloride caused a significant elevation in enzyme levels such as AST, ALT, Total bilirubin and Total protein, this indicated the damaged structural integrity of liver, Due to Carbon tetrachloride inducing agent the levels of SGOT, SGPT, Total bilirubin were elevated and the total protein levels was decline than normal. The pretreatment of B.S.Eth and B.S.Aqs stems extracts at dose levels of 100 and 200 mg/kg were shown a restored the ALT, AST, Total bilirubin and Total protein levels towards normalization and the effects were comparable with standard drug (Silymarin 100 mg/kg). Histopathological evaluation of livers revealed that the B.S. Eth and B.S.Aqs stems extracts reduced inflammation of hepatocytes, swelling, necrosis and no. liver lesions induced by CCl4.

Keywords: Bougainvillea spectabilis, CCl4, AST, ALT, Hepatitis.