PHYTOCHEMICAL INVESTIGATION AND PHARMACOLOGICAL EVALUATION OF BOUGAINVILLEA SPECTABILIS FOR HEPATOPROTECTIVE ACTIVITY
S. K. Sarje*, Kadam V. M., Hede A. B., Ware S. V., Patil V. D. and Jadhav V. R.
ABSTRACT
The presence study aimed to evaluate the Hepatoprotective effect of
Bougainvillea spectabilis stems extract against liver injury induced by
carbon tetrachloride (CCl4). Both male and female wistar albino rats
were used, rats were injected i.p. with CCl4 (1ml/kg) mixed in liquid
paraffin in portion (1:1), three times in a seven days and treated orally
with Bougainvillea spectabilis (100 mg/kg and 200 mg/kg) stems
extract daily for seven days and compared with a group of rats injected
i.p. with CCl4 (1ml/kg) mixed in liquid paraffin in portion (1:1), three
times in a seven days. Bougainvillea spectabilis plant belonging to
family Nyctaginaceae used in various diseases like Hepatitis.(Leaves),
Diarrhea, Inflammation, Stomach acidity, Cough, sore throat and other respiratory diseases,
Leucorrhea, Ulcer, Microbial infection, Diabeties, Hyperlipidemia, Cancer, It have antifertility
property. Carbon tetrachloride caused a significant elevation in enzyme levels such as
AST, ALT, Total bilirubin and Total protein, this indicated the damaged structural integrity
of liver, Due to Carbon tetrachloride inducing agent the levels of SGOT, SGPT, Total
bilirubin were elevated and the total protein levels was decline than normal. The pretreatment
of B.S.Eth and B.S.Aqs stems extracts at dose levels of 100 and 200 mg/kg were
shown a restored the ALT, AST, Total bilirubin and Total protein levels towards
normalization and the effects were comparable with standard drug (Silymarin 100 mg/kg).
Histopathological evaluation of livers revealed that the B.S. Eth and B.S.Aqs stems extracts
reduced inflammation of hepatocytes, swelling, necrosis and no. liver lesions induced by
CCl4.
Keywords: Bougainvillea spectabilis, CCl4, AST, ALT, Hepatitis.
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