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Abstract

PREPARATION AND EVALUATION OF LOPINAVIR HOLLOW MICROBALLOONS BY NON-AQUEOUS SOLVENT EVAPORATION METHOD

A. C. Sindhu* and J. Adlin Jino Nesalin

ABSTRACT

The aim of present study is an attempt to preparation and evaluation of floating hollow microballoons of Lopinavir by using Eudragit S-100 polymer for treating HIV & AIDS related conditions. There are five different formulations (FN1-FN5) are prepared by the Non-aqueous solvent evaporation method. Changing the polymer concentration ratio will significantly affect the in vitro drug release. The formulated hollow microballoons were evaluated for percentage yield, scanning electron microscopy (SEM), particle size, in vitro release and in vitro buoyancy. Among five formulations FN-3 was obtained as ideal formulation. The FTIR studies are indicates that there is no interaction between the drug and polymer. SEM is showing the surface pores and interior of the hollow microballoons. The short term stability studies on the formulations are indicates that there are no physical or chemical changes in the formulations during the study period time. According to the data obtained from Lopinavir hollow microballoons in vitro release showing sustained release over a period of 12 hrs. Thus reduce dose frequency, improve bioavailability which gives better patient compliance.

Keywords: Eudragit S-100, Hollow Microballoons, Lopinavir, Non-aqueous solvent evaporation method.


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