COMPARATIVE NEPHROPROTECTIVE EFFECT OF CINNAMOMUM CASSIA AND ZINGIBER OFFICINALE ON DIABETIC MICE
Priti Kumari*, Sunil Kumar Choudhary, Ashok Ghosh, Arun Kumar, Md. Ali and Ranjit Kumar
ABSTRACT
Diabetes is emerging disease in developed and developing country and
increased exponentially in last few decades. Diabetes has global health
problem. Diabetes mellitus is a metabolic disorder characterized by
chronic hyperglycaemia with disturbances of carbohydrate, fat and
protein metabolism resulting from defects in insulin secretion, insulin
action, or both. Alloxan were introduced intra-peritoneal @ 120
mg/kg/b. w to prepare diabetic model. Diabetic control group mice
were treated with distilled water while diabetic mice were treated with
Cinnamomum cassia @ 100 mg/kg/b. w and Zingiber officinale @ 80
mg/kg/b. w separately for 16 weeks. Glucose level was increased many folds in diabetic
mice. SGPT, urea and uric acid was increased in diabetic group of mice. Cinnamon and
ginger restores PCT, DCT and glomerulus effectively after 16 weeks of administration. It is
concluded from entire study that cinnamon and ginger both acts very effectively against
diabetes on biochemical and histological parameters of mice. Both restore glucose level to
normal level. Cinnamon acts effectively on SGPT, Uric acid; Urea while ginger does not
effectively restore uric acid and SGPT in diabetic mice. Cinnamon effectively restores
glomerulus and bowmen’s capsule very well in comparison to ginger administered group. It
was evident from study that cinnamon causes effective restoration in both biochemical and
histological parameters of mice.
Keywords: SGPT, Uric Acid, glomerulus, hyperglycaemia, alloxan.
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