Abstract

COMPARATIVE NEPHROPROTECTIVE EFFECT OF CINNAMOMUM CASSIA AND ZINGIBER OFFICINALE ON DIABETIC MICE

Priti Kumari*, Sunil Kumar Choudhary, Ashok Ghosh, Arun Kumar, Md. Ali and Ranjit Kumar

ABSTRACT

Diabetes is emerging disease in developed and developing country and increased exponentially in last few decades. Diabetes has global health problem. Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. Alloxan were introduced intra-peritoneal @ 120 mg/kg/b. w to prepare diabetic model. Diabetic control group mice were treated with distilled water while diabetic mice were treated with Cinnamomum cassia @ 100 mg/kg/b. w and Zingiber officinale @ 80 mg/kg/b. w separately for 16 weeks. Glucose level was increased many folds in diabetic mice. SGPT, urea and uric acid was increased in diabetic group of mice. Cinnamon and ginger restores PCT, DCT and glomerulus effectively after 16 weeks of administration. It is concluded from entire study that cinnamon and ginger both acts very effectively against diabetes on biochemical and histological parameters of mice. Both restore glucose level to normal level. Cinnamon acts effectively on SGPT, Uric acid; Urea while ginger does not effectively restore uric acid and SGPT in diabetic mice. Cinnamon effectively restores glomerulus and bowmen’s capsule very well in comparison to ginger administered group. It was evident from study that cinnamon causes effective restoration in both biochemical and histological parameters of mice.

Keywords: SGPT, Uric Acid, glomerulus, hyperglycaemia, alloxan.