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Abstract

SYNTHESIS AND ANALGESIC ACTIVITY OF 4-(2H-PYRIDO-(1,4) OXAZIN-4(3H)-YL SULFONYL) ANILINO-HYDROXYL AMINE

Dr. P.R. Logesh Kumar*, G. Kanchanamala, P. Pavithra, D. Kamala, J. Mounika, P. Priyanka, S. Jithendra and T. Naveen Kumar

ABSTRACT

Morpholine is an organic chemical compound. The heterocyclic features consists of both amine and ether functional groups. Because of the amine function group morpholine acts as a base. Morpholine is a back bone is essential in different pharmacologically active synthetic compounds. Present work summarizes the synthesis of morpholine nucleus and its derivatives. The morpholine and its compounds where synthesized in multistep reaction with more efficient process. Starting compound is available commercially. Starting compound used in this reaction is 2-aminopyridin-3-ol. Morpholine nucleus shows a broad spectrum of pharmaceuticals applications. The chemical structures of the synthesized were confirmed by means of NMR, UV and MASS spectral data. High yield and purity of the derivatives indicates lack of side reaction. In recent years various new method were developed for the synthesis of morpholine analogues. The synthesized compounds and its derivatives were then examined for antibacterial, antifungal and analgesic activities.

Keywords: Morpholine, synthesis, pharmaceutical applications, antibacterial, analgesic, antifungal activity.


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