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Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF O-CHLORO PHENOL DERIVATIVES OF HETEROCYCLE AZOCINE

Dr. P. R. Logesh Kumar*, K.S. Shafiya Kowsar, V. Lavanya, S. Aslam, G. Haritha, M. Sandhya, M. Praveen, Y. Praveen Kumar and S. Malika

ABSTRACT

Azocine is the chemical species of unsaturated eight membered heterocyclic ring with nitrogen as hetero atom. The IUPAC name of Azocine is Azacyclooctatetraene. The saturated or partially saturated azocine rings form the core structure of a group of opioid compounds sometimes known as Azocines. Azocine rings are found in many Natural products. The starting compounds for the synthesis of azocine is Ethyl-3-oxobutanoate. The structural assignments are supported by NMR, MASS, IR spectroscopy and chromatography Thin Layer Chromatography and Paper Chromatography. These include cyclazocine, pentazocine and phenazocine. The compounds possessing interesting biological and pharmacological properties as antiinflammatory, anti-cancer, anti- bacterial, anti-fungal, anti-viral, antiarrhythmic, tranquilizing, muscle relaxing and anti-diabetic agents.

Keywords: Azocine, Ethyl-3-oxobutanoate, Anti fungal activity.


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