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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

SYNTHESIS AND EVALUATION OF DERIVATIVES OF HETEROCYCLE CINNOLINE

Dr. P.R. Logeshkumar*, Dr. P. Vasanthkumar, K. Tharangini, K. Priyanka, M. Sunanda, J. Manjula, S. Varun Kumar, V. Hareeshkumar, M. Chandrashekar, M. Madhu Sudhana

ABSTRACT

Cinnoline is also known as 1,2 diazanaphthalene or benzo-1,2 – diazene. Cinnoline itself is toxic. cinnoline nucleus is very important bicyclic heterocycle that is used as the structural sub unit of many compounds. Cinnoline derivatives exhibit broad spectrum of pharmacological activities such as antibacterial, antifungal, antimalarial, anti inflammatory, analgesic, anxiolytic and antitumour activites. It is soluble in water, ethanol, methanol, DMSO, and DMF. It is a pale yellow solid of geranium like odour. The starting compound of cinnoline is Aniline and Sodium nitrite. Some of the cinnoline derivatives are 4-phenyl cinnoline, Ethyl cinnoline, Methyl cinnoline, Cinoxacin.

Keywords: 1,2-diazanaphthalene, Heterocycle, Anti-fungal, Antimalarial, Anti-inflammatory, Anti-analgesic, Anti-tumor, Antibacterial.

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