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Abstract

SYNTHESIS AND EVALUATION OF DERIVATIVES OF HETEROCYCLE CINNOLINE

Dr. P.R. Logeshkumar*, Dr. P. Vasanthkumar, K. Tharangini, K. Priyanka, M. Sunanda, J. Manjula, S. Varun Kumar, V. Hareeshkumar, M. Chandrashekar, M. Madhu Sudhana

ABSTRACT

Cinnoline is also known as 1,2 diazanaphthalene or benzo-1,2 – diazene. Cinnoline itself is toxic. cinnoline nucleus is very important bicyclic heterocycle that is used as the structural sub unit of many compounds. Cinnoline derivatives exhibit broad spectrum of pharmacological activities such as antibacterial, antifungal, antimalarial, anti inflammatory, analgesic, anxiolytic and antitumour activites. It is soluble in water, ethanol, methanol, DMSO, and DMF. It is a pale yellow solid of geranium like odour. The starting compound of cinnoline is Aniline and Sodium nitrite. Some of the cinnoline derivatives are 4-phenyl cinnoline, Ethyl cinnoline, Methyl cinnoline, Cinoxacin.

Keywords: 1,2-diazanaphthalene, Heterocycle, Anti-fungal, Antimalarial, Anti-inflammatory, Anti-analgesic, Anti-tumor, Antibacterial.


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