SYNTHESIS AND EVALUATION OF DERIVATIVES OF HETEROCYCLE CINNOLINE
Dr. P.R. Logeshkumar*, Dr. P. Vasanthkumar, K. Tharangini, K. Priyanka, M. Sunanda, J. Manjula, S. Varun Kumar, V. Hareeshkumar, M. Chandrashekar, M. Madhu Sudhana
ABSTRACT
Cinnoline is also known as 1,2 diazanaphthalene or benzo-1,2 –
diazene. Cinnoline itself is toxic. cinnoline nucleus is very important
bicyclic heterocycle that is used as the structural sub unit of many
compounds. Cinnoline derivatives exhibit broad spectrum of
pharmacological activities such as antibacterial, antifungal,
antimalarial, anti inflammatory, analgesic, anxiolytic and antitumour
activites. It is soluble in water, ethanol, methanol, DMSO, and DMF. It
is a pale yellow solid of geranium like odour. The starting compound
of cinnoline is Aniline and Sodium nitrite. Some of the cinnoline
derivatives are 4-phenyl cinnoline, Ethyl cinnoline, Methyl cinnoline,
Cinoxacin.
Keywords: 1,2-diazanaphthalene, Heterocycle, Anti-fungal, Antimalarial, Anti-inflammatory, Anti-analgesic, Anti-tumor, Antibacterial.
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