Abstract

FORMULATION AND IN-VITRO EVALUATION OF CANDESARTAN MUCOADHESIVE MICROSPHERE

Sonupriya Nayak and Balwan Singh*

ABSTRACT

Mucoadheshive microsphere of candesartan were prepared by Iongelation technique to achieve increase retention time reduce the frequency of daily administration whose main target is to absorb in the stomach and upper part of intestine by increase the residence time of drug in upper part of GIT and to control the release of drug for longer period of time. Here different mucoadheshive polymer and release retard polymers are used for extend release of drug. Sodium Alginate is used as cross linking agent, carbopol, HPMC are used as mucoadheshive polymer. Mucoadheshive candesartan microsphere were evaluated for the parameters like, Drug content and entrapment efficiency, swelling index, Micrometric property, the surface morphology of microsphere was characterized by SEM, the prepared microsphere were spherical with varied surface roughness, free flowing property, In-vitro wash off test showed prepared microspheres exhibits for mucoadheshive properties, dissolution studies of all 9 formulations were performed for all batches. Formulation 7 contains HPMC based mucoadheshive microsphere showed maximum Drug content and efficiency as compared to other batches.

Keywords: Candesartan, Mucoadhesion, Mucoadhesive polymers, Sodium Alginate.