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Abstract

FORMULATION AND DEVELOPMENT OF IBUPROFEN TABLET: AN IN VITRO STUDY FOR BIOEQUIVALENCE OF NEW FORMULATION

Sharmin Akter Anny, Md. Mominur Rahman, Fahadul Islam, Abdur Rahman, Sadia Afroz, Sharifa Sultana, Sabrina C. Raka, A. K. Azad and Sharif Mohammad Shaheen*

ABSTRACT

Cost effectiveness is a very important think to formulate a product. People can get good product with a low price they must prefer the product. For developing a drug, bioequivalence test must be needed because of ensuring the therapeutic performance of drugs which have undergone changes in manufacturing processes as well as in formulation-modifications. Here we tried to develop a formulation of Ibuprofen tablets (400mg) in a cost-effective way so that people can use effectively with low price. We also evaluated release profile, similarity factor (f2) and mechanical properties of Ibuprofen tablets. This formulation shows a significant similarity with standard (Flamex, ACI Limited) where the similarity factor f₂ was 84% after 60 minutes where it is said that the similarity factor between new developed drug and standard should be at least 80% at 60 minutes. So this new formulation might be a better marketed product with at least one third (1/3) less cost because of the low price of excipients with good quality.

Keywords: Ibuprofen, flamex, bioequivalence, similarity factor, release profile.


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