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Abstract

PEPTIC ULCER: A REVIEW ON ITS ETIOLOGY, PATHOGENESIS AND PHARMACOTHERAPY

Dinesh Kawade*, Nikhil Shahu, Payal Bahadurkar, Payal Hiradewe and Nidhi Dhote

ABSTRACT

A peptic ulcer is a sore on the coating of the stomach or duodenum. The two most regular sorts of peptic ulcer are designated "gastric ulcers" and "duodenal ulcers". Peptic ulcers are seen as because of a lopsidedness between forceful factors, for example, hydrochloric corrosive (HCL), pepsin, refluxed bile, leukotrienes (LTs), responsive oxygen species (ROS) and cautious components, which incorporate the capacity of the bodily fluid bicarbonate obstruction, prostaglandins (PGs), mucosal blood stream, cell restoration and movement, nonenzymatic and enzymatic cancer prevention agents and some development factors. H. pylori contamination and the utilization of nonsteroidal mitigating drugs (NSAIDs) are the dominating reasons for peptic ulcer ailment. Likewise, a quantities of variables are embroiled in the pathogenesis of gastric ulcer, among which main considerations included are bacterial contamination (Helicobacter pylori), certain drugs (NSAID), synthetics (Hcl/ethanol), gastric malignant growth and minor elements are pressure, smoking, fiery nourishment and dietary insufficiencies. The thought behind treating ulcers is to bring down the measure of corrosive that your stomach makes, to kill the corrosive that is made and to ensure the harmed zone so it can have the opportunity to recuperate. The principle point of this survey article needs to condense the ulcerogenic instruments of different middle people, pharmacotherapy associated with Peptic ulcer malady.

Keywords: Peptic Ulcer, Types, Pathogenesis, Mediators and Pharmacotherapy.


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