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Manoj V. Dhoke*, Preethishree C., Usha Verma and Sowmya B. A.


New 2&3-(4 amino benzamido) benzoic acid derivatives have been designed and synthesized by the reaction between Para amino benzoic acid and hydrochloride salts of PABA and was refluxed in good yields and their antibacterial property was evaluated against E.coli and Streptococcus aureus. Docking study was performed by using macromolecule PDB ID: 4P66 with the help of Autodock 4.2. Compounds D8, D10, D13, D14, D17 have been discovered to have a critical ideal docking score in the range of 7.66 to 8.8 kcal/mole which is closer to the ligand methotrexate for the E. coli DHFR protein. Characterization of synthesized compounds was done with the help of its spectral analysis. The structural information of all synthesized derivatives was determined by spectral data obtained from IR, Mass, 1H-NMR, 13C NMR. Most of the newly synthesized compounds as ID D8 showed 90% of MIC for S.aureus and 60% of MIC for E.coli against standard drug Ciprofloxacin (0.2μg/ml). Since the compound D8 exhibits lowest MIC value it showed a better antibacterial against both the bacteria.

Keywords: PABA, E.coli, Streptococcus aureus, Benzamide derivatives, Antibacterial.

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