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Abstract

FORMULATION AND EVALUATION OF NEBIVOLOL HYDROCHLORIDE FAST DISSOLVING TABLETS BY USING HYDROPHILIC POLYMERS

Dr. Sathya Surya Prasad Ch.*, K. Durga Devi, V. Akhila Chandrika K. Swarna Kumari, K. Sree Vidya

ABSTRACT

The purpose of this research was to develop Nebivolol fast dissolving tablets. Nebivolol hydrochloride is the racemate (dl-nebivolol hydrochloride) of the enantiomers l-nebivolol hydrochloride and d- Nebivolol hydrochloride. It is a competitive and highly selective β1 receptor antagonist with mild vasodilation properties, possibly due to an interaction with the L-arginine/nitric oxide pathway. Six formulations of Nebivolol 250 mg were formulated by direct compression technique using different hydrophilic polymer grades such as PEG-400, HPMC K4 were used as polymers in different concentrations and other ingredients are, Micro crystalline cellulose (MCC), sodium starch glycolate (SSG), mannitol, Talc and Magnesium stearate before the formulation the granules are evaluated by pre-compression studies like density, floe properties, FT-IR and DSC. The obtained tablets were evaluated with different post-compression parameters like hardness, friability, thickness, weight variation, In-vitro disintegration studies and In-vitro dissolution studies. The formulation F1 was selected as an optimized formulation because it gives best results in terms of In - vitro drug release in a fast release manner and best fitted to first order model with r value of 0.999.

Keywords: Nebivolol Hydrochloride, PEG-400, HPMC K4M, Micro Crystalline Cellulose (MCC), Sodium Starch Glycolate (SSG), Mannitol, Fast Dissolving Tablets.


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