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Abstract

FORMULATION, OPTIMIZATION AND EVALUATION OF SIMVASTATIN BUCCAL PATCH FOR LOCAL TREATMENT OF PERIODONTITIS

Ashwini R. Madgulkar, Mangesh R. Bhalekar, Sayali S. More* and Shraddha K. Pardeshi

ABSTRACT

The aim and objective of this study was to develop mucoadhesive buccal patch of Simvastatin for the local treatment of periodontitis. Simvastatin has short biological half-life (3 h), high first-pass metabolism and poor oral bioavailability (5%), hence an ideal candidate for buccal (local) delivery system. Simvastatin patch was developed by using mucoadhesive polymer as Chitosan and HPMC K4M as hydrophilic in nature. Propylene glycol 40% of total polymer weight was used as plastisizer. Patch was prepared by solvent casting method. Prepared patches were evaluated using different test such as weight uniformity, thickness, pH, swelling index, folding endurance, In-vitro drug release and permeation studies. The formula was optimized using DOE 32 factorial design and was checked for the effect of Chitosan and HPMC K4M on Folding endurance, % Drug release, Mucoadhesion. It was found that as the concentration of Chitosan and HPMC K4M increases there is decrease in drug release and increase in folding endurance and Mucoadhesion property.

Keywords: Simvastatin, Buccal patch, Periodontitis, Chitosan, HPMC K4M, Mucoadhesion.


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