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Abstract

PEG-400 MEDIATED HIGHLY EFFICIENT AND BENIGN ONE-POT SYNTHESIS OF PYRIMIDONE DERIVATIVES

Vinayak Vishram Kadam*

ABSTRACT

In the current work, I report a capable, exquisite and quick one-pot synthesis of a variety of pyrimidinone derivatives from β-dicarbonyl compounds, urea/thiourea, and various substituted aldehydes by using the synthetic capability of PEG-400 under microwave irradiation, ultrasonic irradiation, reflux, and by stirring method. Microwave and ultrasound methods are found to be excellent for the present purpose. The present synthetic strategy benefits with excellent yields, short reaction time, benign reaction conditions, clean transformation and purification of products by non-chromatographic strategies. Thus represent this elegant protocol an environmentally adequate for dihydropyrimidinone/thione synthesis. Four methods have been deliberately compared to find out the best procedure for the synthesis of 3,4-dihydropyrimidine-2(1H)-ones/thione derivatives. The synthesized products have been characterized by FT-IR, 1H NMR, and 13C NMR Spectral methods.

Keywords: 3, 4-dihydropyrimidine-2(1H)-ones/thiones, Microwave irradiation, Ultrasound irradiation, PEG-400.


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