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Abstract

FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF DICLOFENAC SODIUM

Akarshi Shrivastava, Harish Sharma and Gyanesh Kumar Sahu*

ABSTRACT

Objective: The main objective of this work is to fabricate Diclofenac Sodium transdermal patch to avoid first pass metabolism and to overcome the problems associated with its biological short half-life and fluctuations in plasma concentration upon oral administration. Method: The patch were prepared using Solvent Casting Method, using Methyl cellulose as polymer, Dibutyl phthalate as permeation enhancer and Ethanol: distilled water as solvent. The physical evaluation of the prepared patch include organoleptic observation, moisture uptake, moisture loss, content uniformity test, stability studies, swelling index, folding endurance. The drug release was determined using Franz diffusion cells in phosphate buffer (pH 7.4). Result: The result of physiochemical parameters of the transdermal patch were found satisfactory. Formula F2 produce best result among all patchs with smooth transparent texture and maximum folding endurance with minimum moisture loss and moisture uptake. The patch weight, thickness were found to be uniform. The drug content in F2 was 98%. Stability study indicates that drug remain stable for six months. Conclusion: This work is further aimed to analyse, concentration of drug reaching in the body and to study its effect.

Keywords: Diclofenac Sodium, Transdermal patch and conventional dosage Form


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