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Abstract

THE PHYSICO CHEMICAL & PHYTO-CHEMICAL ANALYSIS OF KANDUPARANGI CHOORANAM (PYGMAEOPREMNA HERBACEA)

Bharath Christian C.B.S.* and Manoharan A.

ABSTRACT

Introduction: Based on WHO guidelines, the herbal products need to be standardized before releasing into the market. Preliminary standardization steps are essential for identification of genuine drug and setting analytical standards. Therapeutic potential of herbal drugs are attributed to the presence of phytochemicals. Kanduparangi Chooranam coded as KC, is a classical Siddha mono herbal formulation chosen from “Gunapadam - Mooligai Vagupu” text book for the management of Iyairaippu which can be correlated in modern medicine as “Bronchial Asthma” as well as the drug is indicated for Vatha, Pitha and Kabha related disorders. Aim and objectives: The study was performed to document the physico-chemical and phytochemical (qualitative) parameters of single-herbal formulation Kanduparangi chooranam (KC). Materials and Methods: The ingredient was authenticated by Department of Medicinal Botany. The raw drug was purified as per standard methods. The drug was dried well in shadow and made into micronized powder. The percentage of total ash, acid-insoluble ash, water soluble ash, and sulphated ash were calculated by the standard methods. The different extracts of the formulation were prepared for the study of extractive value such as alcohol, water soluble extract and for the estimation of pH values. Further estimation such as Loss on drying, total fat, swelling index and foaming index were carried out as per WHO guidelines. Qualitative estimation of phytochemicals were determined by standard methods. Results and Discussion: Organoleptic characters: Colour – mild brownish, Odour- Typical, Taste - Bitter and Astringent and Consistency- powder (chooranam). The physico-chemical parameters were determined, Loss on drying of KC was calculated as 9.60% that denotes moisture content of the drug. Ash values are helpful in determining the quality and purity of the crude drugs in powder form. High ash content explains its unsuitable nature to be used as drug. In this study, the ash content of a crude drug are determined by total- ash 4.43 %, sulphated ash 6.61%, acid- Insoluble ash 0.57% and water- soluble ash 2.03 %. Extractive values of crude drugs, water-soluble extractive 17.14% and alcohol-soluble extractive 14.14% are useful for their evaluation; these values indicate the nature of the constituents present in a crude drug. The pH of the sample had shown 5.97 which is slightly acidic and also swelling Index (3.5 ml), foaming index (100), volatile oil (0.5 %) and total fat (1.29 %) of KC were determined. Preliminary phyto-chemical screening of KC established the presence of chemical constituents like Terpenoids, Quinones, Glycosides, Alkaloids, Lignans and Saponins. Conclusion: The drug Kanduparangi chooranam (KC) is physico and phyto- chemically standardized should take into consideration most of aspects contributing to the quality of the drugs.

Keywords: Physico-chemical, phyto-chemical, Kanduparangi chooranam, Bronchial asthma, Pygmaeopremna herbacea.


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