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Yahkoob Punnakkan*, Ganesh N. S. and Vineeth Chandy


The main aim of any drug delivery system is to attain appropriate concentration of the drug in system or tissue, which is therapeutically effective and non toxic for a prolonged period. One novel approach in this area is GRDDSs (Gastro Retentive Drug Delivery System), can improve the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a prolonged period of time before it reaches its absorption site. Various attempts have been made to develop gastro-retentive delivery systems such as such as floating drug delivery systems (FDDS), swelling and expanding systems, bio-adhesive systems, modified shape systems, high density systems or other delayed gastric emptying devices have been discovered till now. The purpose of writing this review was to investigate, compile and present the recent as well as past literatures in more concise way with special focus on approaches which are currently utilized in the prolongation of gastric residence time. These includes floating system, swelling and expanding system, bio/muco-adhesive system, high density system and other delayed gastric emptying devices. The present review addresses briefly about the classification, formulation consideration for GRDDS, factors controlling gastric retention, merits, demerits, applications of gastro-retentive drug delivery systems. The review also includes details about FDDS and a brief note on granulation technique.

Keywords: Gastro Retentive Drug Delivery System, floating drug delivery systems, granulation technique.

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