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Abstract

A REVIEW ON SAFETY AND EFFICACY OF OXACEPROL AS ANTIINFLAMMATORY DRUG IN THE MANAGEMENT OF OSTEOARTHRITIS

Shivprasad Khose*, Sanjay Bhawar and Santosh Dighe

ABSTRACT

Oxaceprol is commonly used for the treatment of Grade-I and II osteoarthritis of knees or degenerative joint disorders and inflammation of connective tissues and it is a derivative of L-proline which is a recognized drug in the management of osteoarthritis which comes under class of non-steroidal anti-inflammatory drugs (NSAIDs). Oxaceprolacts by inhibiting leukocyte infiltration in synovial joints and late connective tissue changes during inflammatory joint disease. Osteoarthritis is one of the forms of joint disease which signifies a key cause of morbidity and disability, chiefly in the second half of lifespan. Generally, the prescribed dose is 37.5 to 200 mg tablet. In case of administration of dose initially it is given in high dose strength which is decreased gradually with time.

Keywords: Oxaceprol, Osteoarthritis, Anti-inflammatory.


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