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Abstract

OPTIMIZATION AND STANDARDIZATION OF FORMULATION CONTAINING SUPRAMOLECULAR LIPID COMPLEXES OF PSIDIUM GUAJAVA AND ITS BIOACTIVITY EVALUATION

Kajal Gupta*, Pooja Jaiswal, Tarun Kumar Dasgupta and Priscilla M D’Mello

ABSTRACT

The polyphenol rich extracts of leaves of P.guajava were evaluated for chemo profiling and HPLC with respect to standard quercetin. With the HPLC it was calculated that 0.02% quercetin was present in total extracts. After that the complexation with phospholipids was carried out to convert the polyphenols of extracts of leaves of P.guajava into their bio-absorbable lipophilic fraction which improve their pharmacokinetic profile. The activities were evaluated by lipid peroxidation inhibitory activity and anti-inflammatory activity using various in-vitro and in-vivo model. The superiority of the action of complexes has demonstrated the concepts behind the product development of the herbal raw material. In sum the synergism of the bio activity profile of phyto-constituents is possible by their complexation with phospholipids. These complexes were then formulated into granules for bio-enhancement of this supra molecular phospholipid complexes. The activities of these granules were evaluated by lipid peroxidation inhibitory activity and anti-inflammatory activity using various in-vitro and in-vivo model.

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