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Abstract

AN ANESTHETIC AGENT-ETOMIDATE, OXIDATION BY KMNO4 USING ALKALINE MEDIUM: A KINETIC AND SPECTROSCOPIC APPROACH

Huizhen Lin, Sibo Zhang, Yu Wang, Mingxia Du, Xiaoyuan Xu and Jing Huang*

ABSTRACT

The anesthetic agent etomidate was oxidized by alkaline mediated potassium permanganate and the rate of oxidation was studied with the help of UV-VIS spectrophotometer at constant ionic strength 0.01 mol dm-3 which exhibited a stoichiometry of 1:1. With respect to oxidant and reductant it is pseudo first order and fractional order with respect to alkaline medium. Various activation parameters with respect to rate determining steps like Ea (kJ/mol), ΔH# (kJ/mol), ΔS# (J/K/mol) and ΔG# (kJ/mol) were calculated and thermodyanamic quantities are also calculated. The slow step is the rate determining step for which the rate constant was calculated and mechanism derived.

Keywords: Kinetics, Oxidation, etomidate, Permanganate ion.


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