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Abstract

FORMULATION AND EVALUATION OF CELECOXIB LOADED EUGRADIT S100 NANOPARTICLES

Nitin Sajwan*

ABSTRACT

Celecoxib- A selective COX1 & COX2 inhinbitor has shown promising results for treating colon polyps but on the other hand may leads to complication in gastrointestinal region. In this study Celecoxib nanoparticles were prepared by loading the drug in a polymer “Eugradit ® S100”. Drug-excipient compatibility was checked by FTIR spectroscopy. Celecoxib loaded Eugradit ® S100 nanoparticles were prepared by solvent extraction method. Four different formulation (F1, F2, F3 and F4) were prepared by taking different ratios of drug and polymer. Formulations were evaluated for % yield, entrapment efficiency, particle size determination etc. Dissolution study was performed and % drug release was compared with the marketed formulation. Melting point of celecoxib was found 157±0.5C. drug showed maximum absorption at 255nm. Confirmation of functional groups (alcohol, nitro compound, alkyl halides & H-bonded alcohol) was successfully done by IR spectroscopy. From TEM images, prepared nanoparticles were found spherical with the range of 100.54±0.014 nm. Percentage yield of nanoparticles was found to be 80.68±0.69 %. Among four prepared formulations F1 was selected for dissolution studies and % drug release was found to be 60.01% which was better than marketed formulation (40.23%). It can be concluded from the study that the dose of celecoxib can be reduced which can eventually reduce side effect of the drug.

Keywords: Drug delivery, Nanoparticle, Celecoxib, Eugradit ® S100, spectroscopy.


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