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Abstract

MIXTURE DESIGN EXPERIMENT ON FORMULATION DEVELOPMENT AND OPTIMIZATION OF CILNIDIPINE INN TABLET A NEW ERA ON DRUG DELIVERY SYSTEM

Monoj Kumar Shaha, Md. Asmat Ullah, Md. Khirul Mamun, Tasnuva Nairin, Md. Mehdi Hasan*

ABSTRACT

The oral drug delivery system which includes the solid dosages form such as conventional dosages form and immediate release dosages form. The objective of this study was to formulate orodispersible tablets containing empagliflozin by direct compression method with sufficient hardness and rapid disintegration time and to study the effect of functionality differences of super-disintegrants on the tablet properties. Tablet is most popular among the all dosages forms today and recently found mostly accepted tablet dosages forms. Because of its convenience easy to administration, convenience of self administration, compactness and easy for the manufacturing. In number of cases immediate onset of action is required than conventional therapy. Cilnidipine drug is poorly soluble in water and it’s highly soluble in higher pH. In this study drug is solubilize in tween 80 and sodium hydroxide and meglumine solution. And then drug solution binding on Pearlitol SD 200 Sodium hydroxide and meglumine used as a buffering agent for basic media preparation. The drug release rates of tablets which prepared by liquisolid compact have higher solubility and dissolution than conventional tablets. full factorial design was used for optimization of barrier layer. The lag time (t10) and time require for release 90% of drug were selected as dependent variables. Tablets were evaluated for hardness, friability, weight variation, drug content and in vitro drug release.

Keywords: formulation, Cilnidipine, mixture design controlled release, Dissolution.


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