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Abstract

A REVIEW ON NEW DRUG DEVELOPMENT AND TREATMENT REGIMEN OF TUBERCULOSIS

Haritha P. J.*, Dr. Jeena Beegum N., Dr. Shiji Kumarp S. and Dr. Sirajudheen M. K.

ABSTRACT

Tuberculosis (TB) is an infectious disease usually caused mycobacterium tuberculosis bacteria (MTB). TB generally affects the lungs, but can also affect other part of the body. TB is spread through the air when people who have active TB in their lungs cough, spit, speaks or sneeze. Tuberculosis has been a leading cause of death for more than a century. Treatment is long and difficult, commonly used drug for TB are; A 4-month chemotherapy regimen using a combination of 4 drug (rifampicin, isoniazid, ethambutol and pyrzinamide for 2 months, followed rifampicin and isoniazd for 4 months) with cure rates of approximately 90% in human. But there is some problems related to above treatment. isoniazid has very serious liver disease increased in people who are 35 years and older, who use alcohol or illegal injection drugs, rifampicin has a problem of immune-allergic reaction, ethambutol cause ocular toxicity and pyrazinamide has only substantial side effect.

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