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Meghana Paraji Sable* and Apeksha Subhash Shete


In advance drug design technology, a large number of new drug molecules are introduced every year. Due to problems like solubility, stability, Bioavailability, more side effects, many drug molecules shows less biological effects. Low Bioavailability is the serious major problem. But it is curable. Low lipophilicity and Zwitter ion are the factors affecting for low Bioavailability. The object of this review is to enhance the concept of natural compounds as oral bioavailability enhancer. Several compounds include Piperine, Naringin, Curcumin, Glycyrrhizin, Ginger, Quercetin etc. The use of natural drugs is more because these are nontoxic, safe, non-addictive, pharmacologically inert, better therapeutic response. This review also explores the natural drugs from plant and animal sources with biological source, mechanism, uses and dose of drug.[1]

Keywords: Bioavailability, Natural drugs, Bioenhancer, Classification of Bioenhancer.

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