WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

APOPTOSIS INDUCING POTENTIALTY OF SPATHODEA CAMPANULATA BARK AGAINST HEPATOCELLULAR CARCINOMA: HEPG2 CELLS

Shrawan Kumar, Rahul Laxhman Gajbhiye and Shila Elizabeth Besra*

ABSTRACT

Bark extract of Spathodea campanulata (BESC) showed potential activity on glioma cells in our previous study but in its activity on hepatocarcinogenesis of hepatoma cells have not been reported so far. Therefore, in this present study we investigated the apoptosis activity of bark extract of Spathodea campanulata (BESC) on hepatocarcinoma cells. BESC significantly inhibited cell viability in a time and concentration dependent manner in the HepG2 cells. Morphological study showed several signs of apoptosis like chromatin condensation, nuclear fragmentation and formation of apoptotic bodies in the BESC treated cells. Agarose gel electrophoresis and detection of apoptosis by flow cytometric analysis had been also performed to ensure the appreciable number of cells in early & late apoptotic stages of HepG2 cells. Cell cycle phase arrest was observed in the G0/G1 phase and MMP shift assay exhibited significant change in the BESC treated cells. The good performance of S. campanulata towards hepatocellular carcinoma (HCC) cell line confirms it could be used as a natural source of anti-tumor agents with minimum side effects.

Keywords: Hepatocellular carcinoma, Spathodea campanulata, Bark, Apoptosis.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More