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Abstract

DESIGN, FORMULATION AND EVALUATION OF MONTELUKAST SODIUM MOUTH DISSOLVING FILM

Rina Ikhar*, Kamlesh Wadher, Anita Pounikar and Milind Umekar

ABSTRACT

Oral mouth dissolving drug delivery system is considered to be an important alternative to the peroral route for the systemic administration of drugs, as it considered the most convenient, easy, safest route of administration. Mouth dissolving film may be preferred over the mouth dissolving tablets in terms of flexibility and comfort. The aim of this study is to formulate and characterize oral mouth dissolving film of Monteleukast Sodium. Oral films were prepared by a Solvent casting method using HPMC-E 15, Propylene glycol, and other recipients. Films were evaluated for mechanical properties, disintegration time, and in- vitro drug release. From the dissolution study, optimized batch was showed maximum in- vitro drug release 98.22%.

Keywords: Oral Dissolving Film, HPMC E15, Solvent casting technique.


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