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Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE TABLETS OF ANTIBIOTIC USED IN THE TREATMENT OF HELICOBACTER PYLORI INFECTION

Jaydeep B. Pawar*, Atul A. Baravkar and Dnyandev G. Gadhave

ABSTRACT

The main aim of this investigation was to optimize and develop mucoadhesive formulations using the combination of Almond gum (AG) and Carbopol 940 (CP) with Clarithromycin as a model drug and their evaluation. Direct compression technique was employed for the preparation of mucoadhesive tablets. A 3 2 full factorial design (FFD) was constructed where the amounts of AG (X1) and CP (X2) were selected as the independent factors. All formulations were tested for pre and post-compressional parameters. Physical characterization of drug shows good agreement with literature values. FTIR studies showed no evidence of interactions between drug, polymers and excipients. The hardness, friability, weight variation, drug content, mucoadhesive strength, in vitro release were uniform and reproducible. However, the AG and CP markedly affected the mucoadhesion strength and the release profile. As amount of polymers increases mucoadhesive strength increases and drug release decreases. Statistical experimental design and data analysis using response surface methodology is also illustrated. The in vitro release kinetics studies reveal that all formulations fits well with Korsmeyer-Peppas model and the mechanism of drug release is non-Fickian diffusion. The investigation results clearly indicated that, combination of AG and CP be capable of mucoadhesive polymer for drug delivery.

Keywords: Clarithromycin, mucoadhesion, Almond gum, Carbopol 940.


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