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Abstract

DEVELOPMENT AND EVALUATION OF PALIPERIDONE CAPSULE FOR SUSTAINED RELEASE ACTIVITY USING NATURAL POLYMER

Sachin Bhusari*, Tejal Chaudhari and Pravin Wakte

ABSTRACT

The aim of present study was to formulate and evaluate a sustained release capsule of Paliperidone prepared by using natural polymers adopting wet granulation method. Triumfetta rhomboidea is natural polymer extracted from Triumfetta rhomboidea leaves powder by using ethanol. Paliperidone capsule were formulated by using Triumfetta rhomboidea polymer and other excipients to sustain the drug release. Extracted polymer was evaluated for its flow properties. All the prepared capsules were evaluated for weight variation, disintegration time, drug content uniformity and in vitro drug release characteristics. Triumfetta rhomboidea polymer showed excellent flow properties and all values were within the limit. FTIR studies suggested that drug and polymers were compatible and did not show any chemical interaction. weight variation and disintegration time were within the range of pharmacopoeia limit. The formulation F4 shows desired drug release and drug content and i.e. 94.36 0.2 % and 92. 64 ± 0.3% respectively up to 12 h when compared with all other formulations. A lab scale method for extraction of Triumfetta rhomboidea polymer by ethanol precipitation method was developed. Through various evaluations, it was concluded that Triumfetta rhomboidea leaves polymer is an effective natural polymer and acts as a release rate modifier.

Keywords: Triumfetta rhomboidea, Paliperidone, Natural polymer, Sustained release capsule, In-vitro drug release study.


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