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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

CHRONIC METFORMIN, TURMERIC TEA AND LOW-DOSE ACUTE CHLORPROMAZINE ATTENUATE PROGRESSION OF COVID-19: PRELIMINARY STUDY AND REVIEW

Dr. S. E. Oriaifo*, Dr. D. O. Oriaifo and Dr. R. A. Oriaifo

ABSTRACT

The pathobiology of COVID-19 caused by SARS-CoV2 is complex, evolving and intertwined with aging and age-related diseases. The high infectivity of COVID-19 is attested to by the increasing daily infection and mortality figures. The increased neutrophilia and increased neutrophil-to-lymphocyte ratio in COVID-19 may be the key factors responsible for the progressive lung and other organ impairment in this disease. They may also be the central culprits in the early thrombophilia, hypoxia, dysregulation of immune-inflammatory pathways, visceral adiposity, increased plasminogen activator inhibitor-I (PAI-I) and other features of obesity-insulin resistance that may be signatures of the disease. In the present report, the combination of metformin and turmeric tea is shown to statistically significantly (P < 0.05) decrease the cardiometabolic risk factors of increased BMI, cholesterol, FBS, MAP, uric acid and neutrophil-to-lymphocyte ratio which may be relevant both for the metabolic syndrome and COVID-19. The combination of chronic metformin, turmeric plus acute low-dose chlorpromazine also prevented the progress of COVID-19 from a mild flu-like illness to severe disease in an adult patient. The combination of metformin and turmeric tea thus may serve as preventive agents of the disease; and with acute chlorpromazine display enhanced curative effects for COVID-19; functions which are urgent and compelling today especially as preliminary reports suggest decreased vaccine efficacy in the elderly.

Keywords: SARS-CoV2, COVID-19, Metformin, Turmeric, Chlorpromazine, Lung injury, Prevent.


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