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*Matlyuba Sanoyeva, PhD, Munisahkon Gulova, Rakhimbayeva Gulnora, Saidvaliev Farruh DSc and Mekhriniso Avezova


Complex pathobiochemical mechanism of chronic migraine development and difficulty of relieve and preventive therapy, thepolymorphismof clinical picture and frequent vascular complications, such as acute or chronic circulatory disorders in brain vesselslends great relevancein the study of this issue. The only way to prevent the consequences of migraine is to treat itconstantly, prevention of complications and maintenance of general health. The purpose of the study was to study the clinical and neurological and bioelectric features of the course of chronic migraine. We studied 82 (100%) patients with chronic migraine, aged 12 to 47 years. We analysed clinical, neurological, and electroencephalographic researches, the ID-migraine questionnaire, the MIDAS scale with the determination of migraine severity, and the Hamilton scale with the assessment of psychopathological statewere used. Based on the study, it was found that headache by type of hemicrania plays a significant role in the formation of autonomic nervous system (ANS) dysfunction and clinical vascular manifestations. Prolonged migraine paroxysms change the sleep formula, disrupting the normal alternation of sleep-rest mode, undermining the vitality with the development of the psychopathological state, thereby significantly reduces the quality of life. In chronic migraines, there are more severe psychopathological conditions in the form of depression and anxiety disorders, which are associated not only with reactive, but also organic, structural changes in the limbic system of the brain,caused by dystonia/cerebral vascular dyscirculation. Psychopathological status aggravates the course of the disease, disrupts the neuroplasticity of the brain, thereby negatively affects the inter-neuronal connection, with the formation of cognitive dysfunction, daily activity decrease, and a slowdown the recovery of lost neurological functions.

Keywords: migraine, chronic migraine, ID-migraine questionnaire, MIDAS scale.

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