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Abstract

POTENTIAL TRANSDERMAL DELIVERY OF HERBAL DRUG VIA ETHOSOMAL SYSTEM FOR THE TREATMENT OF VARIOUS DISEASES

Alok Debnath*, Shaweta Sharma and P. K. Sharma

ABSTRACT

Background: Ethosomes are transdermal drug delivery system and preferred over other liposomal drugs pertaining to high permeation through skin. The increased permeation is caused due to use of ethanol, which provides important benefits such as improved drug delivery, patient compliance, comfort, easy to administer. Main Text: Ethanol’s have unique structure which helps in encapsulating highly lipophilic molecules such as cannabinoids, testosterone and minoxidil, and some cationic drugs such as propranolol, trihexaphenidyl, Cyclosporine, insulin, salbutamol etc. This types of enhanced drug delivery of bioactive molecules through skin by means of ethosomal carrier cause numerous challenges and opportunities for future development. This review is focused on Advantage, method of preparation, application, evaluation, herbal product and recent patents of Ethosomes. Conclusion: Ethosomes are more stable than other conventional liposomes. They are safe, have more efficacy and long-term stability, and can be manufactured easily. Ethosomes is a new trend of transdermal drug delivery and is successful in delivering through skin. In this system, side effects are minimized and it has better penetration ability. The ability to encapsulate hydrophilic drugs, cationic drugs, proteins and peptides has opened new challenges and opportunities for development of novel improved therapies on the market. Considerable research has been conducted to characterize the novel non-invasive carrier. Such development may further increase the range of transdermal applications.

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