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Abstract

FORMULATION AND EVALUTION OF FAST DISSOLVING TABLET OF SOLID DISPERSION OF LAMOTRIGINE

*Dipali Bhandari, Trusha Shangrapawar, Ashok Bhosale, Amit Lunkad and Narhari Patil

ABSTRACT

Purpose: Lamotrigine belongs to biopharmaceutical classification systems; BCS class II (Low solubility & High permeability). In addition, it requires immediate therapeutic action as it is antiepileptic drug. Hence, the main objective of this study is to improve the solubility by solid dispersion technique and formulate it as fast dissolving tablets to avert the problems of swallowing and to provide rapid onset of action. Method: Lamotrigine solid dispersion was prepared by using solvent evaporation method and fusion method and formulated it into fast dissolving tablet by direct compression technique using different concentrations of Sodium Starch Glycolate, Cross Carmalose Sodium as superdisintegrants. Result: The tablets were evaluated for various parameters and the results were found to be satisfactory. Conclusion: The fast dissolving tablets containing solid dispersion prepared by solvent evaporation technique shows highest drug content. The optimized formulation shows more drug release than other formulation.

Keywords: Solid dispersion, Superdisintegrants, Fast dissolving tablets, Solvent evaporation, Fusion.


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