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Abstract

NANOSUSPENSION: A NOVEL TECHNOLOGY FOR THE DRUG DELIVERY SYSTEM

Suvarna S. Vadje*, Rajendra K. Surwase, Mohini E. Shinde, Kajal R. Patil and Shivraj B. Pagare

ABSTRACT

Poor solubility of the drug decreases the bioavailability of the drug. This problem is more worsen because of more than the 40% of the newly discovered drug product are poorly water soluble. Formulation of these mainly the BCS class II and BCS class IV drug into the conventional dosage form is a challenging problem faced by the pharmaceutical scientist. Nanosuspension can be used to solve the problems of poor bioavailability. Nanosuspension is the colloidal dispersion of the drug particle in an aqueous vehicle, which is stabilized by the surfactant or polymer or both. Nanosuspension increases the saturation solubility and dissolution rate. Nanosuspension can be prepared by the bottom up and top down approaches such as nanoprecipitation, media milling, high pressure homogenization, solvent evaporation etc. Nanosuspension delivered through the various route like oral, parenteral, ocular and topical. The following review article focuses onto the advantages, disadvantages, methods of preparation, characterization and applications of nanosuspension.

Keywords: Nanosuspension, colloid, saturation solubility, dissolution rate, bioavailability


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