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Abstract

A CASE STUDY ON INTERLINK BETWEEN LIVER ABSCESS AND SEPSIS AND THEIR RELATION WITH OTHER DISEASES IN A GERIATRIC PATIENT

Darshana Prakash* and A. R. Shabaraya

ABSTRACT

A case of 60 year old male patient diagnosed with complications of DM, TB, sepsis, liver abscess and jaundice collected from Srinivas hospital was analyzed. The purpose of this case study was to find the interlinking relation between the major complications severe sepsis and liver abscess with each other and with other disease in this patient. This was investigated through manifestation and laboratory findings of this patient. The direct extension of an intraabdominal abscess into the liver via the portal vein from an intraabdominal infection, and indirectly from complications of CD (i.e., biliary disease) is thought to predispose the formation of Liver Abscess. Infections in organs in the portal bed can result in a localized septic thrombophlebitis, which can lead to liver abscess. Septic emboli are released into the porta circulation, trapped by the hepatic sinusoids, and become the nidus for micro abscess formation. This patient with compromised immune status due to diabetes, there was an extensive involvement of the liver. Liver disease can also cause hypoproteinemia by decreasing synthesis of albumin and total protein which is stated true by liver function test of this patient. DM has been associated with increased rates of TB, which may be partially explained by a decreased T cell–mediated immune response. Cholestasis is the predominant mechanism by which jaundice develops in sepsis. Thus we concluded in this case study, it is possible that inflammation of ileum and ilea vessels resulted in thrombosis with subsequent septic emboli to the liver via the portal system resulting in multiloculated abscesses.

Keywords: liver abscess, severe sepsis, infection.


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