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Abstract

A REVIEW ARTICLE ON SYNTHESIS OF IMIDAZOLE DERIVATIVES

Dipanshu Panday*, Dr. Sujeet Gupta, Dr. Bhumika Yogi, Jhilika Singh, Rajvinder Kaur

ABSTRACT

Imidazoles are heterocyclic compounds that have gained greatly from the five-member ring structure, outstanding location for their exceptional pharmacological activities in recent years. The nucleus of imidazole is a major drug discovery synthesis strategy. Imidazole is a five-member planar ring structure with N atom at positions 1 and 3. This compound is systematically named 1, 3, one of the N bear a H atom and one of the pyrrol type N. Imidazole was called glyoxalin for the first time. It is amphoteric and susceptible to electrophilic and nucleophile attack. The 4- amino-imidazole- 5-carboxamide, found naturally as riboside, is a part of purine nucleus and histidine amino acid. This interesting group is characterized by a wide range of biological activities, including analgesic, inflammatory, antiviral, and anthelmintic, anticonvulsant, antimicrobial, anti-allergic, etc. This is the group of heterocyclic compounds. Distinctively large scope is given by various methods for the synthesis of the imidazole and its chemical reactions.

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