COLON TARGETED DRUG DELIVERY SYSTEM: DELIVERY APPROACHES, RECENT ADVANCEMENTS AND PATENTS
Guru Dayal Yadav*, P. K. Sharma and Kalpana Rahate
ABSTRACT
To treat certain intestinal disorders such as Amebiosis, Colonic
cancers, Crohn’s diseases Ulcerative colitis, local colonic pathological
treatment and systemic delivery peptide and protein drugs. Colon
targeted drug delivery system is more acceptable. This article shows
the delivery approaches for colon targeting such as Primary approaches
include prodrugs, pH dependent system, time-dependent systems, and
microbial drug delivery system have achieved limited success.
Mechanical based colon targeted drug delivery approaches such as
Osmotic controlled delivery of drugs, CODESTM and pressure
controlled colonic delivery capsules are unique in terms of the
specificity of the in vivo site and the feasibility of the manufacturing
process and Novel approaches for colon targeted drug delivery such as
Multiparticulate Drug Delivery System, Azo hydrogel, Nanoparticles,
Liposomes and Microsphere can provide therapeutics benefits
including patients compliance, reduce the doses of drug and also lower the cost of drug. This
articles also shows recent advancements in various approaches for designing the colon
targeted drug delivery system and also focused on patents that are accessible on present days
in various colonic delivery.
Keywords: Colon drug delivery system, Time Dependent, pH dependent, Polysaccharides based delivery, Novel Approaches.
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