Abstract

COLON TARGETED DRUG DELIVERY SYSTEM: DELIVERY APPROACHES, RECENT ADVANCEMENTS AND PATENTS

Guru Dayal Yadav*, P. K. Sharma and Kalpana Rahate

ABSTRACT

To treat certain intestinal disorders such as Amebiosis, Colonic cancers, Crohn’s diseases Ulcerative colitis, local colonic pathological treatment and systemic delivery peptide and protein drugs. Colon targeted drug delivery system is more acceptable. This article shows the delivery approaches for colon targeting such as Primary approaches include prodrugs, pH dependent system, time-dependent systems, and microbial drug delivery system have achieved limited success. Mechanical based colon targeted drug delivery approaches such as Osmotic controlled delivery of drugs, CODESTM and pressure controlled colonic delivery capsules are unique in terms of the specificity of the in vivo site and the feasibility of the manufacturing process and Novel approaches for colon targeted drug delivery such as Multiparticulate Drug Delivery System, Azo hydrogel, Nanoparticles, Liposomes and Microsphere can provide therapeutics benefits including patients compliance, reduce the doses of drug and also lower the cost of drug. This articles also shows recent advancements in various approaches for designing the colon targeted drug delivery system and also focused on patents that are accessible on present days in various colonic delivery.

Keywords: Colon drug delivery system, Time Dependent, pH dependent, Polysaccharides based delivery, Novel Approaches.