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Sanket N. Shinde*, Avish D. Maru, Mitesh P. Sonawane, Kajal R. Patil and Uday D. Sonawane


The oral route is the most convenient route for administration of solid dosage form, about 85% of solid dosage administered by oral route because of advantages over others. The therapeutic activity of these formulations is obtained through a typical manner like disintegration followed by dissolution. Hence disintegration has major role for facilitating drug activity. The Fast dissolving drug delivery system (FDDS) technologies brings valuable benefits to patients, life cycles and profits. The objective of the present article is to highlight the various kinds of superdisintegrants along with their role in tablet disintegration and drug release, which are being used in the formulation to provide the safer, effective drug delivery with patient compliance. This review focuses on various synthetic superdisintegrants, natural superdisintegrants from different plant sources. In this article includes requirement for fast dissolving drug delivery system, their advantages, selection of superdisinegrant, various technologies, mechanisms of superdisintegrant, types of superdisintegrant.

Keywords: Fast disintegrating tablets, Superdisinegrants, Oral route, Methods.

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