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Abstract

RETROSPECTIVE STUDY ON PRESCRIBING PATTERN OF GUILLAIN BARRE SYNDROME, A BINATIONAL STUDY, INDIA AND IRAN

*Ali Alipour, Balakeshwar Ramaiah, Mostafa Azadbakht

ABSTRACT

Introduction: Guillain-Barre syndrome (GBS) is an autoimmune and post-infectious immune disease. Guillain-Barre syndrome (GBS) is an acute-onset, monophasic, immune-mediated polyneuropathy that often follows an antecedent infection. Guillain-Barre syndrome is a peripheral neuropathy that causes acute neuromuscular failure. The syndrome includes several pathological subtypes. The diagnosis relies heavily on the clinical impression obtained from the history and examination, although cerebrospinal fluid analysis and electro diagnostic testing usually provide evidence supportive of the diagnosis. Misdiagnosis is common and can be fatal because of the high frequency of respiratory failure, which contributes to the 10% mortality seen in prospective studies. There are currently two treatments commonly used to interrupt immune-related nerve damage. One is plasma exchange (PE, also called plasmapheresis); the other is high-dose immunoglobulin therapy (IV-Ig). Both treatments are equally effective if started within two weeks of onset of GBS symptoms, but immunoglobulin is easier to administer.

Keywords: Guillain-Barre syndrome, autoimmune, plasmapheresis, immunoglobulin.


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