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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

SYNTHESIS, CHARACTERISATION AND BIOLOGICAL EVALUATION OF ETHYL-4-(4-ALKYLPHENYL)-6- METHYLSULFANYLDIENE-1,2,3,4-TETRAHYDROPYRIMIDINE-5- CARBOXYLATE

*Sebastin V., Suma C., Ahmed Rashid K., Fathimath Rahila Jaffar, Mareemath Afreeda K. A., Sahlath K. K. and Thelha N. K.

ABSTRACT

The work include the synthesis of four Derivatives of Ethyl-4-(4- alkylphenyl)-6-methylsulfanyldiene-1,2,3,4-tetrahydropyrimidine-5- carboxylate by one pot multicomponent reaction, involving reaction of Aromatic aldehyde, β keto ester, Thiourea in presence of concHCl and ethanol. The structure of synthesised compound was confirmed by IR spectroscopic analysis. The synthesised compounds were screened for their antibacterial activity against Gram positive bacteria (Enterococcus faecalis and Staphylococcus aureus) and gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa) using Ciprofloxacin 5mg/ml as standard.

Keywords: Pyrimidine, substituted aldehydes, antibacterial.


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