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Abstract

IMPACT OF FIPRONIL ON THE LIVER METABOLISM OF SWISS MALE ALBINO MICE

B. Akhila and CH. Vijaya*

ABSTRACT

The main objective of the present study is to detect the effect of fipronil on the liver of Swiss albino mice. There are very few reports about the effect of fipronil exposure on the mice liver during adults, in the present study 9.5mg/kg body weight, 95mg/kg body weight fipronil was treated by oral gavage to mice. Swiss albino mice were divided into three groups each consisting of six animals i.e. control, group-1, and group-2. The activity levels of Aspartate aminotransferase (AAT), Alanine transaminase (ALT), Succinate dehydrogenase (SDH), and Lactate dehydrogenase (LDH) were significantly (p ≤ 0.05) increased in the liver of all experimental mice compared to control mice. The activity levels of Lipid peroxidation, SOD and Catalase were also significantly (P ≤ 0.05) increased in all Fipronil treated mice compared to control mice liver tissue. From the results of the present study, it is suggested that exposure to fipronil might cause dysfunction of the liver which leads to affect the glucose metabolism and activity levels of antioxidants in animals and humans.

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