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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

THE POTENCY OF HYDROXYCHLOROQUINE TO TREAT COVID- 19 DISEASE

E. M. Sutrisna*

ABSTRACT

Background: several experts’ opinions, theory reviews and case reports on HCQ figure various results. This review is aimed at determining hydroxychloroquine (HCQ) effect on Covid-19 patient. Method: The Review was done by examining publications published in Pubmed and Sciencedirect. Searching process was done by keywords: hydroxychloroquine and covid-19 and randomized clinical trial; research article and published 2020. The criterion for the choice of publications to be reviewed is the complete researches based articles. Result: There were 3 articles meet the criterion. Length of stay (hospitalization) to negative convertion of viral nucleic acid in HCQ vs control group was 4 (1.9) days vs 2 (1.4) days, (Z = 1.27, P>0.05); number of patients who get diarrhea and abnormal liver function between HCQ vs control groups were 4 cases (26.7%)) vs 3 cases (20%) (P>0.05); number of patients who get radiological progression that shown on CT images between HCQ vs control groups were 5 cases (33.3%) vs 7 cases (46.7%); The median time to normalize body temperature in the HCQ vs control group was 1 (0.2) vs 1 (0.3) day). Total negative conversion before 28 days between HCQ (1200mg/day for 3 days followed 800mg/day for2-3 weeks) +standard care group vs standard care group was (56 vs 53 patients of 150 patients). There were 2 HCQ recipients (1200mg/day for 3 days followed 800mg/day for2-3 weeks) were reported to have serious adverse events blurred vision and thirst. Conclusion: There is insufficient evidence that HCQ improve clinical symptom, sign or time hospitalization on covid-19 patients.

Keywords: hydroxychloroquine (HCQ), Covid-19, Review article.


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