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Abstract

REVIEW ARTICLE: RP-HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF TELMISARTAN AND ATORVASTATIN FROM BULK AND PHARMACEUTICAL DOSSAGE FORM

B. Venu G.*, G. Srikanth Reddy and K. Rama Priyanka

ABSTRACT

A simple, accurate, precise RP-HPLC method has been developed and for the estimation of telmisartan and atorvastatin in fixed dosage formulation. The separation was achieved on a C-18 reversed phase column (ACE 5, C-18, 150mm x 4.6mm, 5μ) using Acetonitrile: Water: Orthophosphoric acid (95:5:01 v/v) as mobile phase-B & Acetonitrile: Water: Orthophosphoric acid (5:95:01 v/v) as mobile phase-A at a flow rate of 1.5ml/min and temperature of 250C. The UV detection was carried out at 254nm. The retention time of Telmisartan and Atorvastatin was found to be 9.08 and 14.68min respectively. The method was quantitatively evaluated in terms of Specificity, Linearity, Accuracy, Precision, and Robustness. The calibration curve for Telmisartan and Atorvastatin were linear from the range of 20.01- 120.05μg/ml and 2.5-14.97μg/ml respectively. The main recoveries obtained for Telmisartan and Atorvastatin were 99.9% and 99.2% respectively. The developed method was found to be Specific, Accurate, Precise, Robust and rapid for the simultaneous estimation of Telmisartan and Atorvastatin in Bulk and Tablets 40mg/10mg & 80mg/10mg.

Keywords: Telmisartan and Atorvastatin Tablets, RP-HPLC, Validation and Stability Indicating.


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