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Abstract

POST COMPRESSION EVALUATION AND IN-VITRO DISSOLUTION ASSESSMENT OF VARIOUS MARKETED DICLOFENAC SODIUM TABLETS (50MG) IN INDIA

Shwetha S. Kamath K.*, Asha Hulakoti, Anupama M.K., Shashank Nayak N. and
J. Thimmasetty

ABSTRACT

The aim of this work was to compare the post compressional data and investigate dissolution behavior of five different marketed brands of enteric coated Diclofenac Sodium tablets(50mg) obtained from local pharmacies, Davanagere. Diclofenac Sodium is moderately watersoluble drug which comes under BCS Class (II). All the formulations contain same amount of drug and different number of excipients. These five different brands of diclofenac sodium are tested by considering different parameters according to standard guidelines. In the present study, these brands were compared in terms of diameter, thickness, weight variation, hardness, friability, drug content, disintegration and dissolution. The marketed product Voveran showed 85.93% in three hours when compared to other marketed products. However, Dicloran showed 75.11 % in three hours which was almost nearer to the drug release of Voveran. Furthermore, based on the release report obtained by the dissolution studies, similarity and dissimilarity factor between marketed products were identified. All the parameters studies of preferred marketed tablets of diclofenac Sodium(50mg) showed varied results. However, these results obtained were within prescribed limits.

Keywords: Diclofenac Sodium, weight variation, friability, disintegration, dissolution.


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