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Abstract

DEVELOPMENT OF PHARMACOGENETIC STANDARDS OF THE DECOCTION OF SHIN MIDI (PREMNA INTEGRIFOLIA) GROWN IN SRI LANKA

Swarna Damyanthi Hapuarachchi* and Dinithi Wasana De Silva

ABSTRACT

Sihin Midi (Premna integrifolia, Family – Verbenaceae) also known as Agnimantha in Ayurveda texts. It is a large shrub and has vata kapha shamaka properties. This plant has been used for a wide variety of diseases in Ayurveda and Traditional Medicine in Sri Lanka. Aim of Study: This study was aim to establish pharmacogenetic standards of the decoction of Shin Midi. Materials and Method: Organoleptic properties and microscopical identification of dried roots of Sihin Midi powder were studied. Determination of loss on drying, total ash, acid insoluble ash, water insoluble ash, water soluble extractive and acid soluble extractive values were calculated as per the Ayurveda Pharmacopeia of India. Results: Sihin Midi roots were woody branched, yellowish brown in color and somewhat tortuous to cylindrical in shape. Microscopically observed the presence of characteristic oil globules in the cortical region, prismatic crystals of calcium oxalate were seen in the cortical cells. n- Hexane hot extraction of Sihin Midi roots showed the positive reaction for alkaloids, tannins, saponin, glycosides and flavonoids. TLC profile of n-Hexane extractions of roots powder of Sihin Midi shows UV active zones at 254 nm and 366 nm. Conclusion: The findings from this study facilitated the identification of proper dried raw materials for the preparation of decoction. The Phytochemical analysis of dried roots of Sihin Midi indicted the presence of alkaloids, tannins, glycosides and flavonoids which have potential role in medicinal value. It suggests for further investigation and isolation of biologically active constituents responsible for the obesity.

Keywords: Premna integrifolia, Sihin Midi, pharmacogenetic standards, phytochemicals.


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