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Abstract

ROLE OF COMPLEMENT IN ACTIVATION OF MACROPHAGES

Ettiyeb Lagha*

ABSTRACT

When microbes penetrate the defensive barriers of the host, it faces the most essential element of the innate immune system called complement, which is a group of proteins that are found in the blood circulation and other soluble substances in the body, and it is produced in large quantity by the liver (Janeway et al., 2012, Bohlson et al., 2014). It was discovered by Jules Bordet in the 1890 "as a heat-labile component of normal plasma" (Janeway et al., 2012). It also plays an important role in protecting the body from intracellular and extracellular pathogens as well as its participation in the adaptive immune response (Haskard et al., 2008).

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