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Abstract

COMPARITIVE STUDY OF OXIDATIVE STRESS MARKERS IN DIABETIC AND NON DIABETIC PATIENTS WITH CATARACT

*Dr. Sunayana Bhat and Dr. Vinay P. G.

ABSTRACT

Purpose: This study compared the relationship of Malondialdehyde(MDA-a marker of oxidative stress) and Glutathione (GSH-which is a natural antioxidant) levels in blood and lens between diabetic patients with cataract and non-diabetic patients with cataract. Methods: In a prospective comparative study Blood and lens samples from thirty patients with diabetes and thirty patients without diabetes undergoing cataract surgery were collected and the levels of MDA and GSH were measured and compared and correlated. Results: There was significant increase in MDA levels in lens and blood in diabetic cataract patients. Levels of GSH in lens and blood were significantly lower in diabetic cataract patients.(p value <0.001) Positive „r values‟ were obtained in the correlation between the levels of MDA in blood and lens as well as the levels of GSH in blood and lens. In contrast, the correlation between the levels of MDA and GSH in blood and lens separately gave negative „r values‟ indicating a negative correlation between the two. Conclusions: The increased oxidative stress in the lens of diabetics may be primarily responsible for cataract formation in them at a younger age compared to non diabetics.

Keywords: diabetes, cataract, oxidative stress.


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