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Abstract

EXPERIMENTAL EVALUATION OF ANTI-DIABETIC EFFECT OF PATHA (CISSAMPELOS PAREIRA LINN.) AND GOKSHURA (TRIBULUS TERRESTRIS LINN.) YOG IN STREPTOZOCIN INDUCED DIABETES IN ALBINO RATS

Ruchita Raghunath Kudale* and D. V. Kulkarni

ABSTRACT

In Ayurvedic classical texts; Patha and Gokshura are used in treatment of Prameha. Combination of these drugs i.e. Patha-Gokshura Yoga is mentioned in Yogratnakara for treating Prameha. Both possess Deepan, Strotoshodhana property and have Pramehaghna (Antidiabetic) activity. The present study was performed to evaluate antidiabetic effect of Patha (Cissampelos pareira Linn.) and Gokshur (Tribulus terrestris Linn.) Yog in Streptozocin induced diabetes in albino rats. Patha- Gokshura Yog (Combination of aqueous root extracts of Patha and Gokshura) was administrated orally at three doses-5.4 ml/kg body weight, 7.2 ml/kg body weight, 9.0 ml/kg body weight respectively for 21 consecutive days to diabetic albino rats. Parameters like change in Body weight, Blood glucose level, OGTT, Hematology (WBC, RBC, Haemoglobin, HCT, Platelet count), Organ weight, Biochemistry (ALP, SGPT, SGOT, TGL, Cholesterol, HDL, TP, Creatinine, Urea) were conducted to evaluate hypoglycemic effect. Daily oral treatment with Patha- Gokshura Yog for 21 days in Streptozotocin induced diabetic rats showed significantly decreased glucose levels Patha- Gokshura LD (p<0.001), Patha-Gokshura ID (p<0.001) and Patha-Gokshura HD (p<0.01) in comparison with Disease control animals. The alteration in biochemical parameters in diabetic animals treated with Patha- Gokshura Yog were seen as compared to disease control animals. This shows significant improvement in metabolic functions by oral administration of Patha- Gokshura Yog. The result suggests that the Patha- Gokshura Yog (Combination of aqueous root extracts of Patha and Gokshura) has significant anti- diabetic activity.

Keywords: Diabetes; Gokshura; Patha; Patha- Gokshura Yog; Prameha.


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