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*Dr. Debit Tamuk, Dr. Bishnu Prasad Sarma, Dr. Rajlakshmi Devi, Puspanjali Khound, Partha Pratim Sarma and Himangshu Sarma


Diabetes mellitus is complex metabolic disorder resulting from either insulin insufficiency or insulin dysfunction a hormone that is required to convert sugar, starches and other food into energy. It is becoming the third “killer” of the health of mankind along with cancer, cardiovascular and cerebrovascular disease. The present study was conducted to evaluate the hypoglycemic effect of Solanum Spirale Roxb. Leaves. The air dried leaves were soaked in 500 ml of 95% ethanol in a round flask for 24 hours the process of extraction was done by reflux condensation method using soxhlet apparatus at 60-80 degree Celsius for 9 hours. The extract was concentrated by distillation apparatus. The hypoglycemic effect study was carried out by inducing diabetes in rats by injecting streptozotocin. The diabetic rats were treated with plant extract and standard drug orally once for 14 days. The blood glucose concentration was measured and noted. The serum collected was analyzed for total cholesterol, triglycerides, LDL, HDL, Sr. AST, Sr. ALT, Sr. creatinine. The result of the present study revealed that the ethanolic extract of Solanum spirale Roxb. Leaves possess anti diabetic effect.

Keywords: Diabetes, Hypoglycemic, Solanum spirale ethanol, streptozotocin.

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