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Abstract

FIRST ORDER DERIVATIVE SPECTROSCOPY METHOD FOR SIMULTANEOUS ESTIMATION OF RANITIDINE HCl AND DICYCLOMINE HCl IN ITS COMBINED DOSAGE FORM

Bhumi D. Kantariya*, Urmi Vikani and Ravi Dalsaniya

ABSTRACT

Simple, accurate, precise and reproducible Spectrophotometric method for the simultaneous estimation of Ranitidine Hydrochloride and Dicyclomine Hydrochloride in tablet dosage form. Method is based on UV Spectrophotometric for determination of two drug, by using Methanol as a solvent and diluted the same with 0.1N NaOH, solution. This derivative Spectrophotometric method was developed by recording the absorbance at 222.2 nm (Zero crossing point of RANTD) and at 334.9 nm (Zero crossing point of DICY). This method was validated according to ICH guideline and Linearity range, it was found to be 7.5-37.5 μg/ml and 1-5 μg/ml for RANTD and DICY, respectively. The method could be applied for determination of in its tablet dosage forms without any interference from excipients or endogenous substances. The proposed method is suitable for routine quality control analysis.

Keywords: UV Spectrophotometric; derivative Spectrophotometric method, Ranitidine Hydrochloride (RANTD); Dicyclomine Hydrochloride (DICY); ICH guidelines; Validation.


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