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Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF CHRONOMODULATED DRUG DELIVERY SYSTEM OF MONTELUKAST SODIUM FOR THE TREATMENT OF NOCTURNAL ASTHMA

Kale Aparna*

ABSTRACT

The chronotherapy of a medication may be accomplished by the appropriate timing of conventionally formulated tablets and capsules and the special drug delivery system to synchronize drug concentrations to rhythms in disease activity. The main objective is to find out the circadian rhythm, that is, a suitable indicator that will trigger the release of the drug from the device. It can be concluded that oral chronotropic drugs help in various drug delivery problems such as extensive first pass metabolism, chronotropic behaviour of the diseases and nocturnal dosing thereby increasing the patient compliance and is the future of the drug delivery systems. The Objective of this study is to design and characterize chronomodulated drug delivery system containing Montelukast Sodium, which can be targeted to colon in a pH and time dependent manner, to modulate the drug level in synchrony with the circadian rhythm of nocturnal asthma patients. In the present research work, developed novel dosage forms by using chronopharmaceuticalapproach. this dosage form, taken at bedtime with a programmed start of drug release after 4 to 5 hours, can prevent the nocturnal asthma in patients.

Keywords: Circadian rhythm, Chronomodulated, Time dependent drug delivery, Nocturnal asthma.


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